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Screening System for Drug Discovery Research
In drug discovery research, it is important to identify and purify the protein targeted by a medicine so functional analyses can be performed. However, the identification and purification of a target protein are quite difficult and require a lot of time and labor.
We have developed a screening system (magnetic nanoparticles and automatic screening equipment) for drug discovery research, in collaboration with Professor Hiroshi Handa of the Tokyo Institute of Technology.
The magnetic nanoparticles are carriers for affinity purification. They have the following superior characteristics, in comparison to existing carriers.
Magnetic nanoparticles enable effective chemical bond formation, because they are nano-sized and have excellent dispersibility.
Magnetic nanoparticles exhibit minimal nonspecific protein absorption.
Magnetic nanoparticles are tolerant to organic solvents and can be used to immobilize ligands (molecules that trap target proteins).
The magnetic nanoparticles for affinity purification can facilitate the one-step purification of target proteins.
Moreover, the automatic screening equipment, which performs magnetic separation and dispersion, has enabled the automation of the affinity purification process and the simultaneous treatment of multiple samples, thus saving time and increasing efficiency.
news
- 2011/06/14
- Aphoenix sells the FG beads rights to TAMAGAWA SEIKI.